I don't believe any of the releases have been tested whatsoever against JBoss AS 5.0.1. JBoss AS 4.6 was the last release that was 4.2.3.GA-only, and then with JBoss ESB 4.7 we jumped to supporting JBoss AS 5.1.0.GA.
ESB 4.10 will work well against JBoss AS 5.1.0.GA though, is there a reason you can't use 5.1.0.GA rather than 5.0.1?
I am working with a government agency that has standardized on 5.0.1 as the release that has been tested and cleared.
Just to double check - your agency has standardized on JBoss AS 5.0.1? Not EAP 5.0.1 or SOA-P 5.0.1?
I finally got a few minutes to try the AS 5.0.1 scenario. There are errors on install - the binding service is configured differently from 5.1.0.GA, which you would have to sort out. I don't know what possible errors lie beyond that.