I think I may have found the answer:
Perhaps someone can validate my reasoning:
 JBoss ESB 4.4 shipped with JBoss AS 4.2.2.
 JBoss AS 4.2.2.GA shipped with JBoss Remoting 2.2.2.SP1
So, implementing JBREM-653 patch (https://jira.jboss.org/jira/browse/JBREM-653) should be done in JBoss Remoting 2.2.2.SP1 to minimize unwanted effects?
you run the following command on the jboss-remoting.jar to get the version that a server is using and then patch that version if you need to:
#java -jar jboss-remoting.jar JBossRemoting Version 2.2.2.SP8