It's not worked seems because tinyMCE works with separate document in iframe, so handlers at main page just not getting notified. Just check tinyMCE documentation in order to check how to call some js from editor and use jsFunction to handle such calls.
Thank you, Ilya!
I found a solution, if someone interested here it is:
1. Enable tinymce plugin save:
2. Konfigure this plugin:
<f:param name="save_enablewhendirty" value="true"/>
<f:param name="save_onsavecallback" value="save"/>
3. Define callback save:
<a:jsFunction name="save" action="..." />
and it works fine.