Don't think so. You can of course use e.g. the CLI for making changes that can be applied without requiring restarts.
I thought so,
The reason I asked is that there isn't a efficient way to copy a profile, for example all the stuff under /profile=ha to a new /profile=new-ha . I know there is a feature request to implement a copy command. Now you have to make all the stuff in a cli script, and not all stuff can be made this way (for example the mail and messages subsystems).
So when there is a refresh option, I can (for now) hack my domain.xml together with a perl script, and then refresh.. Then again, strictly the slaves, as running on another server, only need the controller running during certain operations, I think.