Yes there are, if you upgrade the io.netty module in WILDFLY_HOME/modules/system/layers/base/io/netty/main
you will see issues with artemis/messaing/jms remoting.
There was recent upgrade in wildfly master to netty 4.1.x [WFLY-8123] Upgrade Artemis 1.5.3.jbossorg-002 by jmesnil · Pull Request #9651 · wildfly/wildfly · GitHub you can probably apply same patch for upgrade.
Beyond that, you can always bundle whatever version of netty in your deployment and you should be fine
Thank you Tomaz!