There shouldn't be any problems. The DBMS should be unaffected as this is a natural instance for it. On the JBoss-side, as long as the JNDI names are different and the config filename is different, it won't have a problem. You will just need to make explicit calls to the required datasource - or have one as default and the other as the one to which you explicitly refer. YMMV.
Thanks for Replying. Appreciate the input.