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Yes it is possible to integrate GateIn with any ESB.
If you want, you can customise the portal, so it uses some features that are provide through the ESB.
As an example, you can call the ESB to run the workflow for the subscription process to the portal (send an email for confirmation of subscription, wait for the confirmation action, etc...).
This is a very basic sample.
More widely, you can integrate the ESB for any services provided by the ESB.
Thank you, Antoine for a comprehensive answer.